HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydroxy-6-nitroquinoline-3-carboxylic acid → 6-Amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydroxy-6-nitroquinoline-3-carboxylic acid | HCID 13106329 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acid | HCID 13106330 | — |
Reaction Steps
A solution of 3.63 g (14.9 mmol) of 1,2-dihydro-6-nitro-2-oxo-3-quinolinecarboxylic acid and 200 ml of dimethylformamide is hydrogenated using 1 g of Raney nickel catalyst at 52 psi and 23° until the required amount of hydrogen uptake is obtained. The catalyst is filtered off and the filtrate is evaporated to dryness. The residue is treated with ethanol and 3.0 g of the desired product is filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04382089 |
| Source dataset | uspto-grants-1983_05 |
| ORD ID | ord-73a3bd3170bf43e8ba3e0e1af1410cc3 |
| Source note | uspto-grants-1983_05 |