反应详情

A 250 ml flask equipped with a mechanical stirrer was charged with 30 g (95 mmole) of 1-methylamino-4-bromoanthraquinone (purchased from Sandoz), 19.5 g (191 mmole) of acetic anhydride, and 0.23 g of 96% H2SO4. The sludgelike mixture was heated and stirred at 110° for 30 minutes. The reaction mixture was cooled to 0° and 50 ml of H2O was added. After stirring 1/2 hour, 55 ml of 30% NaOH was added and the entire mixture was then transferred to a pressure reactor for the following reaction. A TLC (EtOAc) showed only a single product in the reaction.

1. customA 250 ml flask equipped with a mechanical stirrer
2. temperatureThe sludgelike mixture was heated
3. temperatureThe reaction mixture was cooled to 0°
4. stirringAfter stirring 1/2 hour
5. customthe entire mixture was then transferred to a pressure reactor for the following reaction
6. customin the reaction