反应详情

5.8 g of 2,3-difluoro-6-nitrophenol, 5.0 g of monochloroacetone, 8.0 g of potassium carbonate and 0.8 g of potassium iodide were added to 100 ml of acetone and the mixture was refluxed for 4 hours. After the removal of insoluble material by filtration, the solvent was evaporated and the residue was distributed between chloroform and water. The chloroform layer was washed with water and was dried, then the solvent was evaporated. The residue was treated with n-hexane to provide 5.0 g of 2-acetonyloxy-3,4-difluoronitrobenzene as light yellow crystals with m.p. 61° C.

1. temperaturethe mixture was refluxed for 4 hours
2. customAfter the removal of insoluble material
3. filtrationby filtration
4. customthe solvent was evaporated
5. washThe chloroform layer was washed with water
6. customwas dried
7. customthe solvent was evaporated
8. additionThe residue was treated with n-hexane