反应详情

A mixture of methyl 5-(hydroxymethyl)-3-thiophenecarboxylate (3 g), sodium methoxide (0.2 g) and excess anhydrous dimethylamine in dry methanol (20 ml) was stirred for 24 h at ambient temperature. The solvent was removed in vacuo, water was added and the product was extracted with ethyl acetate. The organic extract was evaporated to leave an oily residue which was chromatographed on silica with ethyl acetate-light petroleum 40°-60°; (1:1) to give the title compound (1.3 g). I.R. (CHBr3) OH 3,595 cm-1 ; C=O 1,620 cm-1

1. customThe solvent was removed in vacuo, water
2. additionwas added
3. extractionthe product was extracted with ethyl acetate
4. extractionThe organic extract
5. customwas evaporated
6. customto leave an oily residue which
7. customwas chromatographed on silica with ethyl acetate-light petroleum 40°-60°