反应详情

温度

200 °C

A mixture of 6 g of the product of Step A and 12 g of pyridinium hydrochloride was heated at 200° C. with stirring for 21/2 hours and the mixture was cooled and diluted with water. Ammonium hydroxide was added to the mixture which was then extracted with methylene chloride. The organic phase was washed with water, dried and evaporated to dryness. The residue was chromatographed over silica gel and was eluted with an 8-2 chloroform-acetone mixture to obtain 4.9 g of 3-(1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)-phenol melting at 155° C.

1. temperaturethe mixture was cooled
2. extractionwas then extracted with methylene chloride
3. washThe organic phase was washed with water
4. customdried
5. customevaporated to dryness
6. customThe residue was chromatographed over silica gel
7. washwas eluted with an 8-2 chloroform-acetone mixture