2-Bromobutane → 1-Sec.-butyl-4-methoxypyrazole

Temperature

70 °C

A mixture of 23.6 g (0.21 mol) of potassium tert.-butylate, 19.6 g (0.2 mol) of 4-methoxypyrazole (for the preparation, see Archiv der Pharmazie 300 (1967), pages 704-708), 100 ml of tetrahydrofuran and 28.7 g (0.21 mol) of sec.-butyl bromide was stirred at 70° C. for 18 hours. 300 ml of water were then added and the mixture was extracted 3 times with 100 ml of chloroform each time. The combined organic phases were dried over sodium sulphate and evaporated in vacuo. 13.2 g (42% of theory) of 1-sec.-butyl-4-methoxypyrazole were obtained from the residue, by vacuum distillation, in the form of a colorless oil with a boiling point of 60° C./0.2 mm Hg.

1. customfor the preparation
2. extractionthe mixture was extracted 3 times with 100 ml of chloroform each time
3. dry with materialThe combined organic phases were dried over sodium sulphate
4. customevaporated in vacuo

ORD record

ord-dea0d5e4ed284266bcee492e9f1ef468

Source dataset

uspto-grants-1983_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04382947