Hydrochloric Acid → HCID 20502659, compound

HRID 851156Notes

Reaction equation

HRID 851156 reaction equation
[ClH:1].Cl.[NH2:3][CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:27]=[CH:26][C:17]3[C:18]4[CH2:25][CH2:24][CH2:23][C:19]=4[C:20](=[O:22])[O:21][C:16]=3[CH:15]=2)[CH2:6][CH2:5]1.[O-:28][C:29]#[N:30].[K+].Cl>O>[ClH:1].[NH:3]([CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:27]=[CH:26][C:17]3[C:18]4[CH2:25][CH2:24][CH2:23][C:19]=4[C:20](=[O:22])[O:21][C:16]=3[CH:15]=2)[CH2:6][CH2:5]1)[C:29]([NH2:30])=[O:28]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11378442Potassium cyanateHCID 20502647HCID 20502647, compound

Product 1

HCID 20502659HCID 20502659, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4.15 g. (0.01 mole) 7-[3-(4-aminopiperidino)-propoxy]-2,3-dihydrocyclopenta[c][1]benzopyran-4(1H)-one dihydrochloride, 4.0 g. potassium cyanate, 50 ml. water and 30 ml. 2 N hydrochloric acid is stirred for 3 days at ambient temperature, filtered and the precipitate extracted with hot ethanol. There are thus obtained 2.4 g. (57% of theory) of the desired compound; m.p. 244°-245° C.

Workup

  1. additionA mixture of 4.15 g
  2. filtrationfiltered
  3. extractionthe precipitate extracted with hot ethanol

Sources & evidence

ORD record
ord-ba77b5ebb25446ae8431afaabc2d0380
Source dataset
uspto-grants-1983_05
Patent number
US04382943

Reaction notes

Loading…