Hydrochloric Acid → HCID 12799202, compound

HRID 851157Notes

Reaction equation

HRID 851157 reaction equation
C([O:4][C:5]1[CH:38]=[CH:37][CH:36]=[CH:35][C:6]=1[C:7]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]2[CH:21]=[CH:22][C:23]3[C:28]4[CH2:29][CH2:30][CH2:31][CH2:32][C:27]=4[C:26](=[O:33])[O:25][C:24]=3[CH:34]=2)[CH2:12][CH2:11]1)=[O:8])(=O)C.Cl>O1CCOCC1>[OH:4][C:5]1[CH:38]=[CH:37][CH:36]=[CH:35][C:6]=1[C:7]([NH:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]2[CH:21]=[CH:22][C:23]3[C:28]4[CH2:29][CH2:30][CH2:31][CH2:32][C:27]=4[C:26](=[O:33])[O:25][C:24]=3[CH:34]=2)[CH2:14][CH2:15]1)=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20502657HCID 20502657, compound

Product 1

HCID 12799202HCID 12799202, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 5.18 g. (0.01 mole) 3-{3-[4-(2-acetoxybenzamido)-piperidino]-propoxy}-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyran-6-one (compound of Example 47), 20 ml. dioxane and 20 ml. 6 N hydrochloric acid is heated under reflux for 10 hours, cooled and filtered. There are obtained 3.0 g. (63% of theory) of the desired compound in the form of its hydrochloride; m.p. 232°-234° C. The corresponding free base melts at 209°-211° C.

Workup

  1. additionA mixture of 5.18 g
  2. temperatureunder reflux for 10 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. customThere are obtained 3.0 g

Sources & evidence

ORD record
ord-1ac2a0bd751040ae8b4a45895052461b
Source dataset
uspto-grants-1983_05
Patent number
US04382943

Reaction notes

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