2-Amino-1-[3-(trifluoromethyl)phenyl]ethan-1-ol → HCID 13079628, compound

HRID 851175Notes

Reaction equation

HRID 851175 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C:21](=O)[CH3:22])=[CH:16][CH:15]=1.[OH:24][CH:25]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=1)[CH2:26][NH2:27]>>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH:21]([NH:27][CH2:26][CH:25]([OH:24])[C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:36])([F:37])[F:35])[CH:29]=2)[CH3:22])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 305142-Amino-1-[3-(trifluoromethyl)phenyl]ethan-1-olHCID 20502759HCID 20502759, compound

Product 1

HCID 13079628HCID 13079628, compound

Procedure

The compound was prepared as in Example 4, from 1-[4-(11-hydroxyundecyloxy)phenyl]propan-2-one (7.3 g) and 2-hydroxy-2-(3-trifluoromethylphenyl)-ethanamine (4.7 g) and purified by chromatography on silica gel in 5% methanol dichloromethane, mp 45°-50° C. as a 50:50 mixture of diastereoisomers.

Workup

  1. custompurified by chromatography on silica gel in 5% methanol dichloromethane, mp 45°-50° C. as a 50:50 mixture of diastereoisomers

Sources & evidence

ORD record
ord-06657a6ddaf4432b9f6c1c1927385498
Source dataset
uspto-grants-1983_05
Patent number
US04382958

Reaction notes

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