3-Isopropylphenol → HCID 13136917, compound

HRID 851188Notes

Reaction equation

HRID 851188 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2].[ClH:11].O=[C:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH:14]1[C:19](O)=[O:20]>>[ClH:11].[CH3:2][CH:1]([C:4]1[CH:9]=[CH:8][C:7]2[C:13]3[CH2:18][CH2:17][NH:16][CH2:15][C:14]=3[C:19](=[O:20])[O:10][C:6]=2[CH:5]=1)[CH3:3]

Participants

3

Reactant 2

HCID 120593-IsopropylphenolHCID 13381780HCID 13381780, compound

Product 1

HCID 13136917HCID 13136917, compoundYield 28.2%

Procedure

Prepared by the method described in Example 1 from 3-isopropylphenol (150 g, 0.66 moles) and 4-oxo-3-piperidinecarboxylate hydrochloride (114 g, 0.59 moles). Recrystallization from dilute aqueous hydrochloric acid yielded the product (46.6 g) as the hydrochloride, mp 257°-261° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from dilute aqueous hydrochloric acid

Sources & evidence

ORD record
ord-2828774bd0554344afccda221dcf135d
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

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