Chloroacetone → HCID 13136937, compound

HRID 851204Notes

Reaction equation

[Cl:1][C:2]1[C:3]([CH3:17])=[CH:4][C:5]2[O:15][C:14](=[O:16])[C:9]3[CH2:10][NH:11][CH2:12][CH2:13][C:8]=3[C:6]=2[CH:7]=1.C(N(CC)CC)C.Cl[CH2:26][C:27](=[O:29])[CH3:28]>>[Cl:1][C:2]1[C:3]([CH3:17])=[CH:4][C:5]2[O:15][C:14](=[O:16])[C:9]3[CH2:10][N:11]([CH2:26][C:27](=[O:29])[CH3:28])[CH2:12][CH2:13][C:8]=3[C:6]=2[CH:7]=1

Participants

Reactant 3

HCID 6571Chloroacetone

HCID 8471Triethylamine

HCID 13136928HCID 13136928, compound

Product 1

HCID 13136937HCID 13136937, compoundYield 27.3%

Procedure

Prepared by the method described for example 26 from 9-chloro-1,2,3,4-tetrahydro-8-methyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one (1.6 g, 0.006 moles), triethylamine (1 ml, 0.007 moles) and 1-chloro-2-propanone (0.57 g, 0.006 moles). Recrystallization from isopropanol gave the product (0.5 g), mp 172°-175° C.

Workup

customPrepared by the method
customRecrystallization from isopropanol

Sources & evidence

ORD record: ord-1d18f9a586ad43b4ab6b0c337cf2e451
Source dataset: uspto-grants-1983_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04382939

Reaction notes

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