Chloroacetone → HCID 13136938, compound

HRID 851205Notes

Reaction equation

HRID 851205 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[C:9]3[CH2:14][CH2:13][NH:12][CH2:11][C:10]=3[C:15](=[O:17])[O:16][C:5]=2[CH:4]=1.Cl[CH2:19][C:20](=[O:22])[CH3:21]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[C:9]3[CH2:14][CH2:13][N:12]([CH2:19][C:20](=[O:22])[CH3:21])[CH2:11][C:10]=3[C:15](=[O:17])[O:16][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 131369188-Methoxy-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one

Product 1

HCID 13136938HCID 13136938, compoundYield 55%

Procedure

Prepared by the method described for Example 26 from 1,2,3,4-tetrahydro-8-methoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one (3.46 g, 0.015 moles) and 1-chloro-2-propanone (2.0 g, 0.022 moles). Recrystallization from methanol gave the product (2.37 g), mp 123°-125° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from methanol

Sources & evidence

ORD record
ord-fe096bce75a04b4ab279f1acc893bdf1
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

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