Hydrogen Bromide → HCID 20502576, compound

HRID 851209Notes

Reaction equation

HRID 851209 reaction equation
C[O:2][C:3]1[C:8]([O:9]C)=[CH:7][C:6]2[C:11]3[CH2:16][CH2:15][N:14]([CH2:17][C:18](=[O:20])[CH3:19])[CH2:13][C:12]=3[C:21](=[O:23])[O:22][C:5]=2[CH:4]=1.[BrH:24]>>[BrH:24].[OH:2][C:3]1[C:8]([OH:9])=[CH:7][C:6]2[C:11]3[CH2:16][CH2:15][N:14]([CH2:17][C:18](=[O:20])[CH3:19])[CH2:13][C:12]=3[C:21](=[O:23])[O:22][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 12899701HCID 12899701, compound

Product 1

HCID 20502576HCID 20502576, compound

Procedure

A solution of 1,2,3,4-tetrahydro-8,9-dimethoxy-3-(2-oxopropyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one (5.0 g, 0.016 moles) in 40 ml of 48% aqueous hydrobromic acid is stirred at reflux for 16 hours. The mixture is cooled, and the precipitated product is filtered and washed several times with cold acetone. The product (5.7 g, mp 280° C. dec.) is used as an intermediate without additional purification.

Workup

  1. temperatureat reflux for 16 hours
  2. temperatureThe mixture is cooled
  3. filtrationthe precipitated product is filtered
  4. washwashed several times with cold acetone
  5. customThe product (5.7 g, mp 280° C. dec.) is used as an intermediate without additional purification

Sources & evidence

ORD record
ord-e17d35fa9a674daf90deac0f19953fb1
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

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