Hydrochloric Acid → HCID 13136960, compound

HRID 851212Notes

Reaction equation

HRID 851212 reaction equation
[CH2:1]([O:3][C:4]1[C:9]([O:10][CH2:11][CH3:12])=[CH:8][C:7]2[C:13]3[CH2:18][CH2:17][N:16]([CH2:19][C:20](=O)[CH3:21])[CH2:15][C:14]=3[C:23](=[O:25])[O:24][C:6]=2[CH:5]=1)[CH3:2].[CH3:26][NH:27][CH3:28].C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:41].Cl.Cl>CO>[ClH:41].[ClH:41].[CH3:26][N:27]([CH3:28])[CH:20]([CH3:21])[CH2:19][N:16]1[CH2:17][CH2:18][C:13]2[C:7]3[CH:8]=[C:9]([O:10][CH2:11][CH3:12])[C:4]([O:3][CH2:1][CH3:2])=[CH:5][C:6]=3[O:24][C:23](=[O:25])[C:14]=2[CH2:15]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 674DimethylamineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 13136947HCID 13136947, compound

Product 1

HCID 13136960HCID 13136960, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared by the method described in Example 38 from 1,2,3,4-tetrahydro-8,9-diethoxy-3-(2-oxopropyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one (35.9 g, 0.10 moles) and dimethylamine (50 g, 1.11 moles). The product is converted to the dihydrochloride with gaseous hydrogen chloride in methanol. An additional recrystallization from methanol/diethyl ether yielded the final product (6.8 g), mp 210° C. (dec.).

Workup

  1. customPrepared by the method
  2. customAn additional recrystallization from methanol/diethyl ether

Sources & evidence

ORD record
ord-aa5fb6f3f85849eb9e0fcf7aac03d66d
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

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