Ethylamine → HCID 13136969, compound

HRID 851214Notes

Reaction equation

HRID 851214 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[O:9][C:10](=[O:21])[C:11]3[CH2:12][N:13]([CH2:17][C:18](=O)[CH3:19])[CH2:14][CH2:15][C:16]=3[C:7]=2[CH:6]=[CH:5][C:4]=1[O:22][CH3:23].[CH2:24]([NH2:26])[CH3:25]>>[CH2:24]([NH:26][CH:18]([CH3:19])[CH2:17][N:13]1[CH2:14][CH2:15][C:16]2[C:7]3[CH:6]=[CH:5][C:4]([O:22][CH3:23])=[C:3]([O:2][CH3:1])[C:8]=3[O:9][C:10](=[O:21])[C:11]=2[CH2:12]1)[CH3:25]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 13136930HCID 13136930, compound

Product 1

HCID 13136969HCID 13136969, compoundYield 55.4%

Procedure

Prepared by the method described in Example 49 from 1,2,3,4-tetrahydro-7,8-dimethoxy-3-(2-oxopropyl)-5H-benzopyrano[3,4-c]-pyridin-5-one (49.6 g, 0.16 moles) and ethylamine (21.2 g, 0.47 moles). Recrystallization from ethyl acetate/hexane yielded the product (30.7 g) as the free base, mp 125°-127° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from ethyl acetate/hexane

Sources & evidence

ORD record
ord-59e4358c23d64a87b82d6a9c8d8962f9
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

Loading…