Methylamine → HCID 13136972, compound

HRID 851217Notes

Reaction equation

HRID 851217 reaction equation
[CH3:1][C:2]1[C:7]([NH:8][C:9](=[O:11])[CH3:10])=[CH:6][C:5]2[C:12]3[CH2:17][CH2:16][N:15]([CH2:18][C:19](=O)[CH3:20])[CH2:14][C:13]=3[C:22](=[O:24])[O:23][C:4]=2[CH:3]=1.[CH3:25][NH2:26]>CO>[CH3:1][C:2]1[C:7]([NH:8][C:9](=[O:11])[CH3:10])=[CH:6][C:5]2[C:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH:19]([NH:26][CH3:25])[CH3:20])[CH2:14][C:13]=3[C:22](=[O:24])[O:23][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 13136944HCID 13136944, compound

Product 1

HCID 13136972HCID 13136972, compoundYield 54.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared by the method described for Example 51 from N-[1,3,4,5-tetrahydro-8-methyl-5-oxo-3-(2-oxopropyl)-2H-[1]benzopyrano[3,4-c]pyridin-9-yl]acetamide (5.1 g, 0.016 moles) and methylamine (2.2 ml, 0.050 moles). Sufficient methanol is added to effect solution. Recrystallization from ethanol gave the product (3.0 g), mp 187°-188° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-61f7c17f6b8e4f57bf9cf511a7b4a0cf
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

Loading…