Methylamine → HCID 13136977, compound

HRID 851220Notes

Reaction equation

HRID 851220 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][C:6]2[C:11]3[CH2:16][CH2:15][N:14]([CH2:17][C:18](=O)[CH3:19])[CH2:13][C:12]=3[C:21](=[O:23])[O:22][C:5]=2[CH:4]=1.[CH3:24][NH2:25]>>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][C:6]2[C:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH:18]([NH:25][CH3:24])[CH3:19])[CH2:13][C:12]=3[C:21](=[O:23])[O:22][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 12899701HCID 12899701, compound

Product 1

HCID 13136977HCID 13136977, compoundYield 291.4%

Procedure

Prepared by the method described for Example 51 from 1,2,3,4-tetrahydro-8,9-dimethoxy-3-(2-oxopropyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one (25.0 g, 0.08 moles) and methylamine (5 g, 0.016 moles). Recrystallization from acetonitrile gave the product (15.5 g), mp 137°-139° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from acetonitrile

Sources & evidence

ORD record
ord-96a76abad5bb44b1a0e1ac1f7171b904
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

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