Ammonia → Benzamide

Participants

Reaction Steps

A solution of 15.4 g (0.1 mole) of 97% phenylglyoxylic acid, 150 g (3 moles) of 34% pure ammonia solution, 1.75 g (0.007 mole) of pentahydrated cupric sulfate and 6 g (0.15 mole) of sodium hydroxide in pellets are heated for 1 hour at 100° C. in an oxygen atmosphere, under agitation, and with a total pressure of 8 bars. Thereafter, after cooling to the ambient temperature, the reaction medium is filtered, thereby isolating 1.05 g (0.0086 mole) of benzamide, M.p.=128°-129° C. The alkaline filtrate is thereafter submitted to repeated extractions with ether.

Provenance & Evidence