Ammonia → Benzamide

HRID 851461Notes

Reaction equation

HRID 851461 reaction equation
[C:1]1([C:7](=[O:11])C(O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH3:12].[OH-].[Na+].O=O>>[C:7]([NH2:12])(=[O:11])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 222AmmoniaHCID 977OxygenHCID 11915Phenylglyoxylic AcidHCID 14798Sodium Hydroxide

Product 1

HCID 2331BenzamideYield 8.6%

Procedure

A solution of 15.4 g (0.1 mole) of 97% phenylglyoxylic acid, 150 g (3 moles) of 34% pure ammonia solution, 1.75 g (0.007 mole) of pentahydrated cupric sulfate and 6 g (0.15 mole) of sodium hydroxide in pellets are heated for 1 hour at 100° C. in an oxygen atmosphere, under agitation, and with a total pressure of 8 bars. Thereafter, after cooling to the ambient temperature, the reaction medium is filtered, thereby isolating 1.05 g (0.0086 mole) of benzamide, M.p.=128°-129° C. The alkaline filtrate is thereafter submitted to repeated extractions with ether.

Workup

  1. filtrationthe reaction medium is filtered

Sources & evidence

ORD record
ord-611b47d05f864b4fa2dca4c025c55837
Source dataset
uspto-grants-1983_05
Patent number
US04385006

Reaction notes

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