反应详情

As described in example 1(b), the reaction is carried out with 125 g (0.3 mol) of 8-[4-chloro-N-(4-methoxyphenyl)-benzamido]-caprylic acid methyl ester, 500 cc. of methanol and 12 g (0.3 mol) of sodium hydroxide. Reaction time: 2 days, reaction temperature: 25° C. 40 g of the crude product (96.3 g) are purified chromatographically on silicic acid using a mixture of chloroform and methanol (99:1) as eluant.

1. customReaction time
2. custom2 days, reaction temperature
3. custom25° C
4. custom40 g of the crude product (96.3 g) are purified chromatographically on silicic acid using
5. additiona mixture of chloroform and methanol (99:1) as eluant