Sodium Hydroxide → 8-[4-Chloro-N-(4-methoxyphenyl)-benzamido]-caprylic acid

Participants

Reaction Steps

As described in example 1(b), the reaction is carried out with 125 g (0.3 mol) of 8-[4-chloro-N-(4-methoxyphenyl)-benzamido]-caprylic acid methyl ester, 500 cc. of methanol and 12 g (0.3 mol) of sodium hydroxide. Reaction time: 2 days, reaction temperature: 25° C. 40 g of the crude product (96.3 g) are purified chromatographically on silicic acid using a mixture of chloroform and methanol (99:1) as eluant.

Provenance & Evidence