反应详情

As described in example 1(b), the reaction is carried out with 7.4 g (18 mmol) of 8-[4-fluoro-N-(4-methoxyphenyl)-benzamido]-caprylic acid methyl ester, 1.4 g (35 mmol) of sodium hydroxide and 70 cc. of methanol. Reaction time: 10 hours, reaction temperature: 25° C. The crude product is further purified chromatographically on silicic acid gel using chloroform as eluant.

1. customReaction time
2. custom10 hours, reaction temperature
3. custom25° C
4. customThe crude product is further purified chromatographically on silicic acid gel