HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 8-[4-Fluoro-N-(4-methoxyphenyl)-benzamido]-caprylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 8-[4-Fluoro-N-(4-methoxyphenyl)-benzamido]-caprylic acid methyl ester | HCID 54385324 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 8-[4-Fluoro-N-(4-methoxyphenyl)-benzamido]-caprylic acid | HCID 20500784 | — |
Reaction Steps
As described in example 1(b), the reaction is carried out with 7.4 g (18 mmol) of 8-[4-fluoro-N-(4-methoxyphenyl)-benzamido]-caprylic acid methyl ester, 1.4 g (35 mmol) of sodium hydroxide and 70 cc. of methanol. Reaction time: 10 hours, reaction temperature: 25° C. The crude product is further purified chromatographically on silicic acid gel using chloroform as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04386031 |
| Source dataset | uspto-grants-1983_05 |
| ORD ID | ord-f5104eb59b8b4ae884f4785c296aa07f |
| Source note | uspto-grants-1983_05 |