Methanol → HCID 13025809, compound

HRID 851661Notes

Reaction equation

HRID 851661 reaction equation
C[O:2][C:3](=[O:30])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)[C:12](=[O:21])[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[Cl:20].[OH-].[Na+].CO>O>[Cl:20][C:14]1[CH:15]=[C:16]([Cl:19])[CH:17]=[CH:18][C:13]=1[C:12]([N:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:30])=[O:2])[C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)=[O:21]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 54022012HCID 54022012, compound

Product 1

HCID 13025809HCID 13025809, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

As described in example 1(b), the reaction is carried out with 35 g (77 mmol), of 8-[2.4-dichloro-N-(4-methoxyphenyl)-benzamido]-caprylic acid methyl ester, 4 g (0.1 mol) of sodium hydroxide, 150 cc. of methanol and 5 cc. of water. Reaction time: 24 hours, reaction temperature: 25° C. The crude product is further purified chromatographically on silicic acid gel using a mixture of n-hexane and ethyl acetate (2:1) as eluant.

Workup

  1. customReaction time
  2. custom24 hours, reaction temperature
  3. custom25° C
  4. customThe crude product is further purified chromatographically on silicic acid gel
  5. additiona mixture of n-hexane and ethyl acetate (2:1) as eluant

Sources & evidence

ORD record
ord-72a95348e7714ad688a63376a574ca7a
Source dataset
uspto-grants-1983_05
Patent number
US04386031

Reaction notes

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