Methanol → HCID 20500781, compound

HRID 851663Notes

Reaction equation

HRID 851663 reaction equation
C[O:2][C:3](=[O:29])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]([C:21]1[C:26]([CH3:27])=[CH:25][CH:24]=[CH:23][C:22]=1[CH3:28])[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1.[OH-].[Na+].CO>O>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:12]([N:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:29])=[O:2])[C:21]2[C:22]([CH3:28])=[CH:23][CH:24]=[CH:25][C:26]=2[CH3:27])=[O:20])=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 54477565HCID 54477565, compound

Product 1

HCID 20500781HCID 20500781, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

As described in example 1(b), the reaction is carried out with 15.8 g (38 mmol) of 8-[4-Chloro-N-(2.6-dimethylphenyl)-benzamido]-caprylic acid methyl ester, 2.2 g (55 mmol) of sodium hydroxide, 100 cc. of methanol and 5 cc. of water. Reaction time: 20 hours, reaction temperature: 25° C. The crude product is further purified chromatographically on silicic acid gel using chloroform as eluant.

Workup

  1. customReaction time
  2. custom20 hours, reaction temperature
  3. custom25° C
  4. customThe crude product is further purified chromatographically on silicic acid gel

Sources & evidence

ORD record
ord-62b85d8dcb424d72a1acc4fe6a26d000
Source dataset
uspto-grants-1983_05
Patent number
US04386031

Reaction notes

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