Triethylamine → HCID 54538189, compound

HRID 851664Notes

Reaction equation

HRID 851664 reaction equation
[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=1.[Cl:20][C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23](Cl)=[O:24].C(N(CC)CC)C>CCOCC>[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=1)[C:23](=[O:24])[C:22]1[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=1[Cl:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 691102-Chlorobenzoyl chlorideHCID 13025817HCID 13025817, compound

Product 1

HCID 54538189HCID 54538189, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

As described in example 3(b), the reaction is carried out with 10 g (35 mmol) of 8-(3-chlorophenylamino)-caprylic acid methyl ester, 6.2 g (35 mmol) of 2-chlorobenzoic acid chloride, 3.9 g (39 mmol) of triethylamine and 100 cc. of ether. Reaction time: 24 hours, reaction temperature: 25° C. The crude product is further purified chromatographically on silicic acid gel using chloroform as eluant.

Workup

  1. customReaction time
  2. custom24 hours, reaction temperature
  3. custom25° C
  4. customThe crude product is further purified chromatographically on silicic acid gel

Sources & evidence

ORD record
ord-7581c12e2bbb46afae00d18634958a7d
Source dataset
uspto-grants-1983_05
Patent number
US04386031

Reaction notes

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