Sodium Hydroxide → HCID 20500792, compound

HRID 851665Notes

Reaction equation

HRID 851665 reaction equation
C[O:2][C:3](=[O:28])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=1)[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19].[OH-].[Na+]>CO>[Cl:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:12]([N:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:28])=[O:2])[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=1)=[O:20]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54538189HCID 54538189, compound

Product 1

HCID 20500792HCID 20500792, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

As described in example 1(b), the reaction is carried out with 3.8 g (9 mmol) of 8-[2-chloro-N-(3-chlorophenyl)-benzamido]-caprylic acid methyl ester, 0.48 g (12 mmol) of sodium hydroxide and 50 cc. of methanol. Reaction time: 24 hours, reaction temperature: 25° C. The crude product is purified chromatographically on silicic acid gel using chloroform as eluant.

Workup

  1. customReaction time
  2. custom24 hours, reaction temperature
  3. custom25° C
  4. customThe crude product is purified chromatographically on silicic acid gel

Sources & evidence

ORD record
ord-ade08ba413da432f93a8928e90a859c3
Source dataset
uspto-grants-1983_05
Patent number
US04386031

Reaction notes

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