Triethylamine → HCID 54446148, compound

HRID 851666Notes

Reaction equation

HRID 851666 reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=1.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH:31]=[C:32]([O:36][CH3:37])[C:33]=1[O:34][CH3:35])[C:28](Cl)=[O:29].C(N(CC)CC)C>CCOCC>[CH3:1][O:2][C:3](=[O:22])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:21])[F:20])[CH:13]=1)[C:28](=[O:29])[C:27]1[CH:26]=[C:25]([O:24][CH3:23])[C:33]([O:34][CH3:35])=[C:32]([O:36][CH3:37])[CH:31]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 13025818HCID 13025818, compound

Product 1

HCID 54446148HCID 54446148, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

As described in example 3(b), the reaction is carried out with 6.3 g (20 mmol) of 8-[3-(trifluoromethyl)-phenylamino]-caprylic acid methyl ester, 6.9 g (30 mmol) of 3.4.5-trimethoxybenzoic acid chloride, 2.5 g (25 mmol) of triethylamine and 150 cc. of ether. Reaction time: 24 hours, reaction temperature: 25° C. The crude product is used in the next reaction step without further purification.

Workup

  1. customReaction time
  2. custom24 hours, reaction temperature
  3. custom25° C

Sources & evidence

ORD record
ord-09e70f6eaee84038a3bfb85e90004c9f
Source dataset
uspto-grants-1983_05
Patent number
US04386031

Reaction notes

Loading…