Sodium Hydroxide → HCID 20500790, compound

HRID 851667Notes

Reaction equation

HRID 851667 reaction equation
C[O:2][C:3](=[O:36])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=1)[C:12](=[O:25])[C:13]1[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[C:15]([O:23][CH3:24])[CH:14]=1.[OH-].[Na+]>CO>[CH3:24][O:23][C:15]1[CH:14]=[C:13]([CH:18]=[C:17]([O:19][CH3:20])[C:16]=1[O:21][CH3:22])[C:12]([N:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:36])=[O:2])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:33])([F:34])[F:35])[CH:27]=1)=[O:25]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54446148HCID 54446148, compound

Product 1

HCID 20500790HCID 20500790, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

As described in example 1(b), the reaction is carried out with 8.6 g (16.8 mmol) of 8-{3.4.5-trimethoxy-N-[3-(trifluoromethyl)-phenyl]-benzamido}-caprylic acid methyl ester, 0.96 g (24 mmol) of sodium hydroxide and 100 cc. of methanol. Reaction time: 24 hours, reaction temperature: 25° C. The crude product is further purified chromatographically on silicic acid gel using chloroform as eluant.

Workup

  1. customReaction time
  2. custom24 hours, reaction temperature
  3. custom25° C
  4. customThe crude product is further purified chromatographically on silicic acid gel

Sources & evidence

ORD record
ord-29c7351bc0704dea8e8574dc6d8630c1
Source dataset
uspto-grants-1983_05
Patent number
US04386031

Reaction notes

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