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HRID851679

反应详情

EQUATION

反应方程式

HRID 851679 的结构方程式

REACTANTS

反应物

2
结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OCCCCCCI)CC[C@]4(C)[C@H]3CC[C@]12C
HCID12805525

未命名化合物

结构：O=C1NC(=O)c2ccccc21.[K]
HCID24194345

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OCCCCCCN5C(=O)c6ccccc6C5=O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID13179027

未命名化合物

收率 89.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A mixture of 6-(5-cholesten-3β-yloxy)hexyl iodide (1.0 g) and potassium phthalimide (1.0 g) in DMF (25 ml) is heated with stirring for 0.5 hours at 85°-90° C. (bath temperature). The mixture is filtered and the filtrate is evaporated in vacuo to a residue that is partitioned between chloroform and water. The organic layer is washed with aqueous sodium thiosulfate and water, dried, and evaporated to a syrup that crystallizes upon standing. Recrystallization from petroleum ether gives the title compound (0.92 g, 89%) mp 80° C.

WORKUP

后处理

  1. temperatureis heated
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated in vacuo to a residue that
  4. customis partitioned between chloroform and water
  5. washThe organic layer is washed with aqueous sodium thiosulfate and water
  6. customdried
  7. customevaporated to a syrup that
  8. customcrystallizes
  9. customRecrystallization from petroleum ether