N2,N5-Bis[3-(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosylthio)propionyl]-L-ornithine → N2,N5-Bis[3-(alpha-D-mannopyranosylthio)propionyl)-L-ornithine

Participants

Reaction Steps

A solution of 36 (100 mg) in MeOH-H2O-Et3N 5:4:1 (v/v/v, 3 ml) is kept for 3 hours at room temperature, and evaporated to a residue which is put on a Sephadex G-25 column and eluted with water. The desired fractions are combined and lyophilized to give the title compound (65 mg, 100%): NMR (D2O)δ: 5.38 (d, J1,2 =15 Hz), 5.35 (d,J1,2 =1.5 Hz) (H-1), 2.70 (t), 2.63 (t) (SCH2CH2).

Provenance & Evidence