HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Diaminobenzoic acid → 2-(2-(difluoromethyl)-4-(2-morpholinoethoxy)phenyl)-1H-benzo[d]imidazole-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Diaminobenzoic acid | HCID 198069 | — |
| Reactant | 2-(Difluoromethyl)-4-(2-morpholinoethoxy)benzaldehyde | HCID 83854627 | — |
| Product | 2-(2-(difluoromethyl)-4-(2-morpholinoethoxy)phenyl)-1H-benzo[d]imidazole-7-carboxylic acid | HCID 178524245 | 48% |
Reaction Steps
2,3-Diaminobenzoic acid (1; 222 mg, 1.5 mmol) and the corresponding 2-(difluoromethyl)-4-(2-morpholinoethoxy)benzaldehyde 124 were subjected to the same general procedure detailed above to afford 2-(2-(difluoromethyl)-4-(2-morpholinoethoxy)phenyl)-1H-benzo[d]imidazole-7-carboxylic acid 125 (300 mg, 48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846947B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-0a317f28990942a3b134fb224e52afbd |
| Source note | uspto-grants-2014_09 |