Triethylamine → 7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide

HRID 851876Notes

Reaction equation

HRID 851876 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].Cl.[CH:15](N)=N.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]2[NH:1][CH:15]=[N:13][S:10](=[O:11])(=[O:12])[C:3]=2[CH:4]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10313058Methanimidamide, hydrochloride (1:1)HCID 112526652-Amino-5-methoxybenzenesulfonamide

Product 1

HCID 574238877-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

There is stirred for 1 night at 80° C. a suspension of 3.0 g of 2-amino-5-methoxybenzene-sulphonamide in the presence of 1.31 g of formamidine hydrochloride and 2.27 ml of triethylamine in 50 ml of toluene. The toluene is evaporated off in vacuo. The residue is taken up in water and the precipitate is filtered off.

Workup

  1. customThe toluene is evaporated off in vacuo
  2. filtrationthe precipitate is filtered off

Sources & evidence

ORD record
ord-bdd68e4875d4449a9297ea8e0e29d07a
Source dataset
uspto-grants-2007_08
Patent number
US07253161B2

Reaction notes

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