Pyridine → HCID 86595485, compound

HRID 851883Notes

Reaction equation

HRID 851883 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[O:7]=[S:8]1(=[O:32])[C:13]2[CH:14]=[C:15]([O:18][C:19]3[CH:20]=[C:21]([C:25](=[N:27][OH:28])[NH2:26])[CH:22]=[CH:23][CH:24]=3)[CH:16]=[CH:17][C:12]=2[N:11]2[CH2:29][CH2:30][CH2:31][C:10]2=[N:9]1.N1C=CC=CC=1>CN(C=O)C>[O:32]=[S:8]1(=[O:7])[C:13]2[CH:14]=[C:15]([O:18][C:19]3[CH:20]=[C:21]([C:25](=[N:27][O:28][C:2]([O:4][CH2:5][CH3:6])=[O:3])[NH2:26])[CH:22]=[CH:23][CH:24]=3)[CH:16]=[CH:17][C:12]=2[N:11]2[CH2:29][CH2:30][CH2:31][C:10]2=[N:9]1

Participants

5

Reactant 3

HCID 1049PyridineHCID 10928Ethyl chloroformateHCID 86595484HCID 86595484, compound

Product 1

HCID 86595485HCID 86595485, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

65 μl (0.65 mmol) of ethyl chloroformate are added dropwise to a solution, cooled to 0° C., of the product obtained in Step A (244 mg, 0.65 mmol) in 1.5 ml of DMF and 59 μl (0.72 mmol) of pyridine. Stirring is carried out at 0° C. for 30 minutes and precipitation of the reaction mixture is brought about using water. The precipitate is filtered off to yield the title product.

Workup

  1. customprecipitation of the reaction mixture
  2. filtrationThe precipitate is filtered off

Sources & evidence

ORD record
ord-3b6f49222a874836b09885b691e9d896
Source dataset
uspto-grants-2007_08
Patent number
US07253163B2

Reaction notes

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