HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Pyrrolidin-1-ylmethyl)aniline → 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Pyrrolidin-1-ylmethyl)aniline | HCID 776852 | — |
| Reactant | 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid | HCID 67202138 | — |
| Product | 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide | HCID 67201704 | — |
Reaction Steps
2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid 159 was coupled with 4-(pyrrolidin-1-ylmethyl)aniline 160 to produce 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide (Compound 869) using the same general procedure outlined in Example 39. MS (ESI) calcd for C31H32F3N5O: 547.26; found: 548 [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846947B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-0539bb62776c46c1a37ae3165f4815f2 |
| Source note | uspto-grants-2014_09 |