HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178527158, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 3-{4-[(5,5-Dioxido-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]benzyl}-1,2,4-oxadiazole-5(4H)-thione | HCID 178527157 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178527158 | HCID 178527158 | — |
Reaction Steps
The product obtained in Step B (290 mg, 0.68 mmol) in ethanol (12 ml) in the presence of NaBH4 (77 mg, 2.03 mmol) is stirred at ambient temperature for 1 hour. 10 ml of 1N HCl are added and extraction (CH2Cl2) is carried out. The title product is purified by chromatography on a silica column (CH2Cl2/MeOH 99/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253162B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-23cdee3be82f42f897905f9b1a265e4c |
| Source note | uspto-grants-2007_08 |