Hydrochloric Acid → HCID 178527158, compound

HRID 851900Notes

Reaction equation

HRID 851900 reaction equation
[O:1]=[S:2]1(=[O:29])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:25]=[CH:24][C:16]([CH2:17][C:18]4[NH:22][C:21](=[S:23])[O:20][N:19]=4)=[CH:15][CH:14]=3)[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:26][CH2:27][CH2:28][C:4]2=[N:3]1.[BH4-].[Na+].Cl>C(O)C>[O:29]=[S:2]1(=[O:1])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:25]=[CH:24][C:16]([CH2:17][C:18]4[NH:22][C:21](=[S:23])[O:20][N:19]=4)=[CH:15][CH:14]=3)[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:26][CH2:27][CH2:28][CH:4]2[NH:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 1785271573-{4-[(5,5-Dioxido-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]benzyl}-1,2,4-oxadiazole-5(4H)-thione

Product 1

HCID 178527158HCID 178527158, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product obtained in Step B (290 mg, 0.68 mmol) in ethanol (12 ml) in the presence of NaBH4 (77 mg, 2.03 mmol) is stirred at ambient temperature for 1 hour. 10 ml of 1N HCl are added and extraction (CH2Cl2) is carried out. The title product is purified by chromatography on a silica column (CH2Cl2/MeOH 99/1).

Workup

  1. extractionextraction (CH2Cl2)
  2. customThe title product is purified by chromatography on a silica column (CH2Cl2/MeOH 99/1)

Sources & evidence

ORD record
ord-23cdee3be82f42f897905f9b1a265e4c
Source dataset
uspto-grants-2007_08
Patent number
US07253162B2

Reaction notes

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