Hydrochloric Acid → HCID 69198141, compound

HRID 851904Notes

Reaction equation

HRID 851904 reaction equation
[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16]([O:18]C)=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1.Cl.[OH-:28].[Na+]>>[NH2:3][S:2]([C:7]1[CH:8]=[C:9]([CH:10]=[CH:11][C:6]=1[N:5]1[CH2:23][CH2:24][CH2:25][C:4]1=[O:28])[O:12][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=1)[C:16]([OH:18])=[O:17])(=[O:26])=[O:1]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69414424HCID 69414424, compound

Product 1

HCID 69198141HCID 69198141, compound

Conditions

Temperature
95 °C

Procedure

A suspension of the product obtained in Step A (1.1 g, 2.55 mmol) in 18 ml of 1N NaOH is heated at 95° C. until a solution is obtained. The solution is allowed to return to ambient temperature, is acidified with 1N HCl and extracted (CH2Cl2). The organic phases are combined, washed (saturated NaCl), dried (MgSO4) and evaporated. The residue is triturated in Et2O; the title product precipitates out and is recovered by filtration.

Workup

  1. customis obtained
  2. customto return to ambient temperature
  3. extractionextracted (CH2Cl2)
  4. washwashed (saturated NaCl)
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customThe residue is triturated in Et2O
  8. customthe title product precipitates out
  9. filtrationis recovered by filtration

Sources & evidence

ORD record
ord-adc6694200354603bd574a2eea76fbad
Source dataset
uspto-grants-2007_08
Patent number
US07253162B2

Reaction notes

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