p-Toluidine → 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-p-tolyl-1H-benzo[d]imidazole-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	p-Toluidine	HCID 7813	—
Reactant	2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid	HCID 67202138	—
Product	2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-p-tolyl-1H-benzo[d]imidazole-4-carboxamide	HCID 67202242	—

Reaction Steps

2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid 159 was coupled with p-toluidine 161 to produce 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-p-tolyl-1H-benzo[d]imidazole-4-carboxamide (Compound 870) using the same general procedure outlined in Example 39. as the starting material. MS (ESI) calcd for C27H25F3N4O: 478.20; found: 479 [M+H].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846947B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-b608400dd2164445873a89842f0999eb
Source note	uspto-grants-2014_09