Hydrochloric Acid → 3-(Hydroxymethyl)pyridin-2(1H)-one

Temperature

110 °C

At RT, 23.2 g (144 mmol) of hexamethyldisilane and 0.781 g (7.19 mmol) of chlorotrimethylsilane are added to a suspension of 10.0 g (71.9 mmol) of 2-hydroxynicotinic acid in 100 ml of toluene, and the mixture is stirred with a KPG stirrer at 110° C. for 30 min. The mixture is then cooled to −40° C., and 22.5 g (158 mmol) of a 1 molar solution of diisobutylaluminium hydride in dichloromethane are added dropwise to the solution. The mixture is thawed to RT, stirred at RT for 18 h and finally, at −10° C., adjusted to pH=4 with dilute hydrochloric acid, and 500 ml of methanol are added such that the temperature does not exceed −10° C. The precipitate formed is filtered off, 100 ml of water are added to the filtrate, the mixture is stirred at 50° C. for 1 h and the precipitate is filtered off. Concentration of the filtrate gives 8.55 g (95% of theory) of the desired compound.

1. temperatureThe mixture is then cooled to −40° C.
2. customis thawed to RT
3. stirringstirred at RT for 18 h
4. customat −10° C.
5. additionare added such that the temperature
6. customdoes not exceed −10° C
7. customThe precipitate formed
8. filtrationis filtered off
9. addition100 ml of water are added to the filtrate
10. stirringthe mixture is stirred at 50° C. for 1 h
11. filtrationthe precipitate is filtered off

ORD record

ord-01f0ea0c06b34f01bbb6314a5a902914

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08846934B2