Sodium Hydroxide → HCID 69507417, compound

HRID 851986Notes

Reaction equation

HRID 851986 reaction equation
C[O:2][C:3]([C:5]1([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][N:15]([S:24]([C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)(=[O:26])=[O:25])[C@@H:16]3[CH2:22][CH2:21][CH2:20][CH2:19][NH:18][C:17]3=[O:23])=[CH:10][CH:9]=2)[CH2:7][CH2:6]1)=[O:4].[OH-].[Na+]>CO>[Cl:33][C:30]1[CH:31]=[CH:32][C:27]([S:24]([N:15]([CH2:14][C:11]2[CH:10]=[CH:9][C:8]([C:5]3([C:3]([OH:4])=[O:2])[CH2:6][CH2:7]3)=[CH:13][CH:12]=2)[C@@H:16]2[CH2:22][CH2:21][CH2:20][CH2:19][NH:18][C:17]2=[O:23])(=[O:25])=[O:26])=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69507325HCID 69507325, compound

Product 1

HCID 69507417HCID 69507417, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(4-{[(4-Chloro-benzenesulfonyl)-((R)-2-oxo-azepan-3-yl)-amino]-methyl}-phenyl)-cyclopropanecarboxylic acid methyl ester (0.03 g, 0.06 mmol) was dissolved in MeOH (1 ml) and treated with 1 N NaOH (0.07 ml) for 24 hr at 50° C. The reaction mixture was concentrated under reduced pressure and purified directly using preparative RP(C18) chromatography: lyophilisate 8 mg; MS: m/e=475.0 (MH+).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. custompurified directly

Sources & evidence

ORD record
ord-d080d59cfcff4ac9abab4b65e08eeeb2
Source dataset
uspto-grants-2007_08
Patent number
US07253158B2

Reaction notes

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