Bromine → HCID 10275621, compound

HRID 852039Notes

Reaction equation

HRID 852039 reaction equation
[CH3:1][C:2]([CH3:27])([CH3:26])[CH2:3][N:4]([CH3:25])[C:5]1[N:10]=[C:9]([NH:11][CH3:12])[N:8]=[C:7]([NH:13][C:14]2[CH:15]=[C:16]([CH:21]=[CH:22][C:23]=2[CH3:24])[C:17]([NH:19][CH3:20])=[O:18])[CH:6]=1.C(=O)(O)[O-].[Na+].[Br:33]Br>C(Cl)Cl>[Br:33][C:6]1[C:7]([NH:13][C:14]2[CH:15]=[C:16]([CH:21]=[CH:22][C:23]=2[CH3:24])[C:17]([NH:19][CH3:20])=[O:18])=[N:8][C:9]([NH:11][CH3:12])=[N:10][C:5]=1[N:4]([CH2:3][C:2]([CH3:27])([CH3:26])[CH3:1])[CH3:25]

Participants

5

Reactant 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 58928540HCID 58928540, compound

Product 1

HCID 10275621HCID 10275621, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-{6-[(2,2-Dimethyl-propyl)-methyl-amino]-2-methylamino-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide (33 mg), aq. sat. sodium bicarbonate (0.05 mL) and bromine (14 mg) were stirred in methylene chloride (1 mL) at room temperature for 4 hours. The product (14 mg) was purified with preparative thin layer chromatography. MS (m/z): 449 (M+1).

Workup

  1. customThe product (14 mg) was purified with preparative thin layer chromatography

Sources & evidence

ORD record
ord-6e484bf3e008466c830fbfc4405c2e0e
Source dataset
uspto-grants-2007_08
Patent number
US07253174B2

Reaction notes

Loading…