Bromine → HCID 10137827, compound

HRID 852040Notes

Reaction equation

HRID 852040 reaction equation
[CH3:1][C:2]([CH3:26])([CH3:25])[CH2:3][NH:4][C:5]1[N:10]=[C:9]([NH:11][CH3:12])[N:8]=[C:7]([NH:13][C:14]2[CH:15]=[C:16]([CH:21]=[CH:22][C:23]=2[CH3:24])[C:17]([NH:19][CH3:20])=[O:18])[CH:6]=1.C(=O)(O)[O-].[Na+].[Br:32]Br>C(Cl)Cl>[Br:32][C:6]1[C:7]([NH:13][C:14]2[CH:15]=[C:16]([CH:21]=[CH:22][C:23]=2[CH3:24])[C:17]([NH:19][CH3:20])=[O:18])=[N:8][C:9]([NH:11][CH3:12])=[N:10][C:5]=1[NH:4][CH2:3][C:2]([CH3:26])([CH3:25])[CH3:1]

Participants

5

Reactant 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 58928526HCID 58928526, compound

Product 1

HCID 10137827HCID 10137827, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-[6-(2,2-Dimethyl-propylamino)-2-methylamino-pyrimidin-4-ylamino]-4,N-dimethyl-benzamide (35 mg), aq. sat. sodium bicarbonate (0.05 mL) and bromine (21 mg) were stirred in methylene chloride (1 mL) at room temperature for overnight. The product (4 mg) was purified with preparative thin layer chromatography. MS (m/z): 435 (M+H).

Workup

  1. customThe product (4 mg) was purified with preparative thin layer chromatography

Sources & evidence

ORD record
ord-c1fcc8b5b43f4b1cbc1a9a675c4511c6
Source dataset
uspto-grants-2007_08
Patent number
US07253174B2

Reaction notes

Loading…