4,6-Dichloro-5-nitropyrimidine → (6-Chloro-5-nitro-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-methyl-amine

HRID 852052Notes

Reaction equation

HRID 852052 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.Cl.[CH3:13][NH:14][CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17].CCN(C(C)C)C(C)C>CC(C)=O>[Cl:11][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:14]([CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH3:13])[C:7]=1[N+:8]([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 203124,6-Dichloro-5-nitropyrimidineHCID 81531DiisopropylethylamineHCID 22393520(2,2-Dimethylpropyl)(methyl)amine hydrochloride

Product 1

HCID 58928507(6-Chloro-5-nitro-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-methyl-amine

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4,6-Dichloro-5-nitro-pyrimidine (0.20 g, 1.0 mmol), N-methyl-neopentylamine hydrochloride (0.14 g) and DIEA (0.2 mL) were stirred in acetone (5 mL) at 0° C. for 4 hours. The solvent was removed in vacuo and the crude product was used for the next reaction without purification.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe crude product was used for the next reaction without purification

Sources & evidence

ORD record
ord-f4886ded2a2d4c2fb1f4a159156b785e
Source dataset
uspto-grants-2007_08
Patent number
US07253174B2

Reaction notes

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