Ethyl cyanoacetate → HCID 17785308, compound

HRID 852058Notes

Reaction equation

HRID 852058 reaction equation
[CH2:1]([NH:6][C:7]([NH2:9])=[O:8])[C:2]([CH3:5])([CH3:4])[CH3:3].[C:10]([CH2:12][C:13](OCC)=[O:14])#[N:11]>CC[O-].[Na+]>[NH2:11][C:10]1[N:6]([CH2:1][C:2]([CH3:5])([CH3:4])[CH3:3])[C:7](=[O:8])[NH:9][C:13](=[O:14])[CH:12]=1

Participants

4

Reactant 2

HCID 7764Ethyl cyanoacetateHCID 22179591HCID 22179591, compound

Product 1

HCID 17785308HCID 17785308, compound

Reagents, catalysts & solvents 1

HCID 2723922Sodium ethoxideSolvent

Procedure

N-neopentylurea (13.0 g, 0.1 mol) and ethyl cyanoacetate (10 ml) were heated in 4N NaOEt (100 ml) for 4 hours under reflux. The reaction mixture was evaporated to dryness, the residue treated with water (100 ml) and then acidified with AcOH to pH 4–5 to form a colorless precipitate. Yield: 11.2 g (59%).

Workup

  1. temperatureunder reflux
  2. customThe reaction mixture was evaporated to dryness
  3. additionthe residue treated with water (100 ml)
  4. customto form a colorless precipitate

Sources & evidence

ORD record
ord-a259a5158e55478d8299f8adc30ed0fa
Source dataset
uspto-grants-2007_08
Patent number
US07253176B1

Reaction notes

Loading…