Dimethyl Sulfate → HCID 14905832, compound

HRID 852059Notes

Reaction equation

HRID 852059 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][C:9]([CH3:12])([CH3:11])[CH3:10])[C:6](=[O:13])[NH:5][C:4](=[O:14])[CH:3]=1.[CH3:15]OS(OC)(=O)=O>[OH-].[Na+]>[NH2:1][C:2]1[N:7]([CH2:8][C:9]([CH3:11])([CH3:10])[CH3:12])[C:6](=[O:13])[N:5]([CH3:15])[C:4](=[O:14])[CH:3]=1

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 17785308HCID 17785308, compound

Product 1

HCID 14905832HCID 14905832, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

6-Amino-1-neopentyluracil (90c) (5.9 g, 0.03 mol) were dissolved in 1 N NaOH (50 ml) and then under vigorous stirring dimethylsulfate (3.9 ml, 0.033 mol) dropwise added at room temp. A precipitate separated and was collected after 2 hours. After washing with water and drying in a vacuum desiccator resulted 5.76 g (91%) of colorless crystals.

Workup

  1. additiondropwise added at room temp
  2. customA precipitate separated
  3. customwas collected after 2 hours
  4. washAfter washing with water
  5. customdrying in a vacuum desiccator

Sources & evidence

ORD record
ord-8aa4f9e6d54a492da30669c00d4b7780
Source dataset
uspto-grants-2007_08
Patent number
US07253176B1

Reaction notes

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