反应详情

To a suspension of 2-(benzyloxy)isonicotinic acid (12.6 g) and potassium hydrogencarbonate (8.3 g) in N,N-dimethylformamide (180 mL) was added dropwise iodomethane (4.8 mL) under ice-cooling, and then stirred at room temperature for 7 hours. The reaction solution was diluted with water, and extracted with ethyl acetate. The organic layer was washed with saturated ammonium chloride (×3), and then dried over anhydrous sodium sulfate and concentrated to give the title compound as a brown oil (13.07 g).

1. temperaturecooling
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with saturated ammonium chloride (×3)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated