Benzenemethanamine, 3,4-dichloro- → HCID 17906276, compound

HRID 852102Notes

Reaction equation

HRID 852102 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:16]3[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:15]=3[O:14][N:13]=2)=[CH:8][CH:7]=1.[Cl:22][C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][C:30]=1[Cl:31])[CH2:26][NH2:27].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(#N)C>[Cl:22][C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][C:30]=1[Cl:31])[CH2:26][NH:27][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:16]3[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:15]=3[O:14][N:13]=2)=[CH:8][CH:7]=1

Participants

6

Reactant 4

HCID 1608Benzenemethanamine, 3,4-dichloro-HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 17906346HCID 17906346, compound

Product 1

HCID 17906276HCID 17906276, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared from a mixture of 3-[4-(3-bromo-propoxy)-phenyl]-6-fluoro-benzo[d]isoxazole, 3,4-dichlorobenzylamine, potassium carbonate, potassium iodide and 4% aqueous acetonitrile essentially as described above in Example 13. Purity by LC/MS=95%, [M+H]+=445.

Sources & evidence

ORD record
ord-b3c8a57837c546019eaef3dec4cdb702
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

Loading…