HRID852127

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19092497

未命名化合物

结构：Fc1ccc2c(-c3ccc(OC[C@H]4CO4)cc3)noc2c1

HCID58928269

未命名化合物

PRODUCTS

生成物

结构：CN(CCn1nc(-c2cccc(Br)c2)c2cnccc21)C[C@@H](O)COc1ccc(-c2noc3cc(F)ccc23)cc1

HCID58928282

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The title compound is prepared from a mixture of (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and {2-[3-(3-bromo-phenyl)-pyrazolo[4,3-c]pyridin-1-yl]-ethyl}-methyl-amine (Table No. 1, SM 6) in ethanol essentially as described above in Example 21. Purity by LC/MS=100%, [M+H]+=616.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-79fa013aa2574e87ba83da578476c942
来源数据集: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07253165B2
来源说明: uspto-grants-2007_08

反应 SMILES

[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.[Br:22][C:23]1[CH:24]=[C:25]([C:29]2[C:33]3[CH:34]=[N:35][CH:36]=[CH:37][C:32]=3[N:31]([CH2:38][CH2:39][NH:40][CH3:41])[N:30]=2)[CH:26]=[CH:27][CH:28]=1>CN(C)C=O.C(O)C>[Br:22][C:23]1[CH:24]=[C:25]([C:29]2[C:33]3[CH:34]=[N:35][CH:36]=[CH:37][C:32]=3[N:31]([CH2:38][CH2:39][N:40]([CH3:41])[CH2:19][C@@H:17]([OH:18])[CH2:16][O:15][C:12]3[CH:11]=[CH:10][C:9]([C:6]4[C:5]5[CH:20]=[CH:21][C:2]([F:1])=[CH:3][C:4]=5[O:8][N:7]=4)=[CH:14][CH:13]=3)[N:30]=2)[CH:26]=[CH:27][CH:28]=1