(S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole → HCID 9891629, compound

HRID 852135Notes

Reaction equation

HRID 852135 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.[N:22]1([C:28]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[NH:30][N:29]=2)[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>CN(C)C=O.C(O)C>[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@@H:17]([OH:18])[CH2:19][N:25]4[CH2:26][CH2:27][N:22]([C:28]5[C:36]6[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=6)[NH:30][N:29]=5)[CH2:23][CH2:24]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 11254641(S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazoleHCID 148234453-(Piperazin-1-YL)-1H-indazole

Product 1

HCID 9891629HCID 9891629, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared from a mixture of (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 3-piperazin-1-yl-1H-indazole (Table No.1, SM 3) in ethanol essentially as described above in Example 21. Purity by LC/MS=100%, [M+H]+=488.

Sources & evidence

ORD record
ord-b7738e4f96ca4402a4bb5200842c2a41
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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